Table 1.

PICO/ Inclusion and Exclusion Criteria

	Inclusion Criteria	Exclusion Criteria
Research Design	RCTs	Observational studies, case-control studies, case reports, theses
Language	English	Non-English
Population	Paediatric and adult patients in primary care settings including care home, rehabilitation centre, specialist clinics. and acute care settings which include chest pain clinic, intensive care units, ambulatory care unit within acute care hospital	Patients from mental health institution Patients from mother and baby units
Intervention	Exposure to advanced nurse practitioner-led / advanced practice nurse-led intervention or service	Exposure to nurse-led interventions or services that lack advanced or specialist training
Comparator	Physician-led care (care provided by medical doctors) or usual care (care provided by medical doctors or non-advanced practice nurse)	Comparators comprising health professionals other than physicians
Outcomes	Resource utilization outcomes, health status, morbidity, mortality, quality of life, satisfaction, knowledge, adherence Preferences, length of stay Re-admission, re-attendance, need for admission, cost, other exploratory outcomes	-