Table 1.
PK parameters (mean ± SEM) of CBD following single oral dose administration of one of four different dosage forms.
| Pharmacokinetic parameter | OM (n = 7) | NM (n = 6) | WM (n = 6) | CM (n = 6) | p-value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC0-t (μg/L*h) | 1432.06 | ± | 208.38 | 853.29 | ± | 188.83 | 1158.98 | ± | 317.83 | 296.05 | ± | 41.22 | 0.0431 a |
| AUC0-inf (μg/L*h) | 1494.14 | ± | 209.87 | 935.19 | ± | 200.42 | 1308.98 | ± | 378.85 | 313.84 | ± | 41.92 | 0.0381 a |
| Cmax (μg/L) | 270.10 | ± | 31.88 | 175.35 | ± | 28.19 | 314.30 | ± | 81.09 | 92.29 | ± | 21.45 | 0.1329 a |
| Tmax (h) | 3.21 | ± | 0.82 | 2.00 | ± | 0.37 | 2.58 | ± | 0.80 | 2.83 | ± | 0.70 | 0.6584 |
| T1/2 (h) | 8.47 | ± | 1.31 | 10.19 | ± | 1.35 | 10.23 | ± | 4.05 | 9.56 | ± | 1.01 | 0.4796 |
| Ke (1/h) | 0.10 | ± | 0.02 | 0.08 | ± | 0.01 | 0.11 | ± | 0.03 | 0.08 | ± | 0.01 | 0.4467 |
| Vz/F (L/kg) | 55.94 | ± | 19.80 | 93.93 | ± | 15.01 | 64.48 | ± | 12.88 | 141.75 | ± | 20.30 | 0.0199 |
| CL/F (L/h/kg) | 4.00 | ± | 0.85 | 7.00 | ± | 1.80 | 5.59 | ± | 1.31 | 10.54 | ± | 1.61 | 0.0381 |
| MRTinf (h) | 8.96 | ± | 0.27 | 9.77 | ± | 1.11 | 10.69 | ± | 3.66 | 8.14 | ± | 0.75 | 0.5032 |
a
A value of p ≤ 0.05 was defined as significant and indicated the data with dose-normalization where applicable.
CBD infused in an oil base (OM), a nanoemulsion base (NM), a water-soluble base (WM), or a semi-solid form (CM) in the OM, NM, WM and CM groups, respectively, where p values are based on post hoc multiple comparisons using Brown-Forsythe ANOVA and otherwise (underlined) using non-parametric Kruskal-Wallis test.