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. 2024 Apr 24;15:1387585. doi: 10.3389/fphar.2024.1387585

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Copyright © 2024 Cai, Tong, Sun, Yao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Funnel plots of ACR20 (A), ACR50 (B), ACR70 (C), DAS28(CRP) < 2.6 (D) response rates at 12 week. Funnel plots of ACR20 (E), ACR50 (F), ACR70 (G) DAS28(CRP) < 2.6 (H) response rates at 24 week. A: Placebo; B: tofacitinib 5 mg; C: baricitinib 4 mg; D: upadacitinib 15 mg; E: upadacitinib 30 mg; F: filgotinib 200 mg; G: peficitinib 100 mg; H: peficitinib 150 mg; I: tofacitinib 5 mg + csDMARD; J: baricitinib 2 mg + csDMARD; K: baricitinib 4 mg + csDMARD; L: upadacitinib 15 mg + csDMARD; M: upadacitinib 30 mg + csDMARD; N: filgotinib 200 mg + csDMARD; O: peficitinib 100 mg + csDMARD; P: peficitinib 150 mg + csDMARD; Q: Conventional synthetic disease-modifying antirheumatic drugs (csDMARD).