FIGURE 4.

PCA and protein‐protein interactions of datasets. (a) Venn diagram of Study 1 and Study 2 showing the overlap of the two sets. (b) PCA plot constructed using the proteins that overlap in the Venn diagram. The first three components are shown with mucosa and tumour‐derived EVs in blue and red, respectively. (c) Enrichment network with the overlapping proteins as input. Nodes represent KEGG pathways. The size of the nodes corresponds to the number of genes in that particular pathway that were identified in the input list. Proteins are represented by either blue (downregulated) or red (upregulated) dots, and edges indicate to which pathway they belong. Three clusters were pulled out from the body of the network and accentuated by red (generally upregulated) or blue (generally downregulated) clouds.