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. 2024 Feb 6;3(2):e127. doi: 10.1002/jex2.127

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© 2024 The Authors. Journal of Extracellular Biology published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Quantitative differences in proteins between tumours tissue‐derived EVs and mucosa‐derived EVs. (a) Volcano plots of the proteins common for both sets. The dotted lines indicate the cut off, which is 1.3 on the Y‐axis (corresponding to a p‐value of 0.05) and 1 on the X‐axis (corresponding to a fold change of 2). Red is representative of an enrichment in tumour‐derived EVs while blue represents a decrease. (b) The top 10 upregulated and top 10 downregulated proteins in each study according to fold change (red and blue dotted lines intercept the y‐axis at a fold change of 2). (c) Pie chart showing the portion of significantly regulated proteins that are membrane proteins. (d) The top 10 upregulated and top 10 downregulated membrane proteins in tumour tissue EVs.