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. 2024 Jan 31;3(2):e92. doi: 10.1002/jex2.92

FIGURE 1.

FIGURE 1

Expression of ISG15 and ISGylation enzymes in patient ascites and ascites derived cells: (a and b) Elevated ISG15 expression shown in HGSOC patient ascites and primary ovarian tumours (POT) by ELISA (n = 16) and in different primary ascites derived ovarian cancer cells (POCCs) by western blot (n = 5). (c) Comparison of ISGylated proteins in normal ovarian surface epithelial cells (OSE1&2) and patient derived ascites cells (POCC1‐5) (n = 5). (d) TEM images of extracellular vesicles in normal OSE cells and in ascites cells (POCC1) (n = 3). (e) Western blot comparison of ISG15 and USP18 expression in OSE cells and POCCs (n = 3). (f and g) Comparison of ISGylation profile and ISGylation enzymes’ expression in normal OSE cells and POCCs.