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. 2024 Jan 31;3(2):e92. doi: 10.1002/jex2.92

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© 2024 The Authors. Journal of Extracellular Biology published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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ISG15 expression in ascites and serum as prognostic biomarker in HGSOC mouse models and patients. (a–c) sEV quantification in OVCAR4 and TR127 transplanted mice serum and ascites (n = 3). (d) Relative expression of ISG15 and USP18 in primary and metastatic mouse ovarian cancer tissue compared to ascites by ELISA (n = 6). (e and f) sEV levels in control and HGSOC patient serum samples (n = 3). (g) ISG15, USP18 and CA125 expression in healthy control and HGSOC patient serum sEV (n = 15). (h) ROC curves based on ELISA results from small EVs isolated from controls and HGSOC serum samples analysed the ISG15, USP 18 and CA125 (n = 12).