FIGURE 4.

Features in the high and low confidence EV sets. Proteins in the high confidence EV dataset, which was constructed from three recent studies show a similar distribution of physicochemical and structural properties as the EV protein set of the discovery dataset. For many features, the discrepancy with the non‐EV group becomes more distinct. Furthermore, the low confidence dataset (orange) which contains EV proteins identified in older studies dilutes the observed signal compared to the EV protein set probably due to many falsely included contaminants. p‐values are displayed in the plots. EV, extracellular vesicle; HC, high confidence; LC, low confidence.