FIG. 2.

Cell cycle regulation of the SWI/SNF complex. The activity of hSWI/SNF is regulated, at least in part, by phosphorylation of some of its subunits. The complex is activated after G₁ by a cyclin E/cdk2-dependent phosphorylation event of BAF155 and BRG1. Phosphorylation toward the end of G₂, which might also occur at the level of BRG1, inactivates it, while a dephosphorylation even occurring late in G₂ also seems to have an activating role in SWI/SNF function. The question marks denote the lack of information concerning how these two apparently contradictory sets of data are related.