FIGURE 1.

Types of extracellular vesicle (EV) and extracellular RNA. Schematic diagram to represent the types of RNA found associated with extracellular vesicles (EVs), along with other co‐isolated extracellular RNAs. A number of extracellular complexes, such as RNAs and RNA binding proteins (RBPs), RNAs and Argonautes, or vault particles containing vault RNA (vtRNA) can also be found within/associated with EVs. Argonautes have also been reported in non‐membrane‐bound exomeres (Q. Zhang et al., 2019; H. Zhang et al., 2018). RBP‐RNA complexes can contain different RNAs such as messenger RNA (mRNA) or microRNA (miRNA) molecules. Although only ribosomal RNA (rRNA) and transfer RNA (tRNA) fragments are illustrated within EVs, other RNA fragments such as mRNA fragments, may also be present