Fig. 1.
(A) A schematic illustration of a filovirus particle is presented. Four proteins are involved in the formation of the ribonucleoprotein complex: polymerase or large protein (L), nucleoprotein (NP), virion structural protein 30 (VP30), VP35. The glycoprotein (GP) is a type I trans membrane protein and is anchored with the carboxy-terminal part in the virion membrane. The soluble GP (sGP) is a non-structural glycoprotein secreted from infected cells and is only secreted by Ebolaviruses. VP40 and VP24 are membrane-associated proteins. (B) Schematic representation of Ebola virus (EBOV) and Marburg virus (MARV) genomes.