Table 2. Antifungal susceptibility profile of isolates of Candida spp. of patients with oral candidiasis who underwent liver transplantation.
| Species | Collection A (n=15) | ||||||
|---|---|---|---|---|---|---|---|
| Antifungal | MIC Variation (μg/mL) | MIC50 (μg/mL) | MIC90 (μg/mL) | Sensitive n (%) | SDD n (%) | Resistant n (%) | |
| C. albicans (n=9) | Fluconazole | 0.125-8 | 0.25 | 4 | 8 (88.9) | 1 (11.1) | - |
| Amphotericin B | 0.25-2 | 0.5 | 1 | 9 (100) | - | - | |
| Micafungin | 0.03-0.5 | 0.03 | 0.03 | 9 (100) | - | - | |
| C. glabrata (n=3) | Fluconazole | 0.125-4 | 0.25 | - | 3 (100) | - | |
| Amphotericin B | 0.25-1 | 1 | 3 (100) | - | - | ||
| Micafungin | 0.03-0.5 | 0.03 | 3 (100) | - | - | ||
| C. dubliniensis (n=1) | Fluconazole | 0.5 | 0.5 | 1 (100) | - | - | |
| Amphotericin B | 0.5 | 0.5 | 1 (100) | - | - | ||
| Micafungin | 0.03 | 0.03 | 1 (100) | - | - | ||
| C. tropicalis (n=2) | Fluconazole | 4-8 | 4 | - | 1 (50) | 1 (50) | |
| Amphotericin B | 0.5-1 | 0.5 | 2 (100) | - | - | ||
| Micafungin | 0.03-0.03 | 0.03 | 2 (100) | - | - | ||
| Collection B (n=15) | |||||||
| C. albicans (n=9) | Fluconazole | 0.125-8 | 0.25 | 8 | 6 (66.7) | 2 (22.2) | 1 (711.1) |
| Amphotericin B | 0.25-2 | 0.5 | 1 | 9 (100) | - | - | |
| Micafungin | 0.03-0.5 | 0.03 | 0.03 | 9 (100) | - | - | |
| C. glabrata (n=3) | Fluconazole | 0.5-1 | 0.5 | - | 3 (100) | - | |
| Amphotericin B | 0.25-1 | 1 | 3 (100) | - | - | ||
| Micafungin | 0.03-0.5 | 0.03 | 3 (100) | - | - | ||
| C. dubliniensis (n=2) | Fluconazole | 0.125-2 | 0.5 | 2 (100) | - | - | |
| Amphotericin B | 0.5-1 | 0.5 | 2 (100) | - | - | ||
| Micafungin | 0.03-0.03 | 0.03 | 2 (100) | - | - | ||
| C. tropicalis (n=1) | Fluconazole | 4 | 4 | - | 1 (100) | - | |
| Amphotericin B | 0.06 | 0.06 | 1 (100) | - | - | ||
| Micafungin | 0.03 | 0.03 | 1 (100) | - | - | ||
MIC: minimum inhibitory concentration; C: Candida; SDD: dose-dependent sensitivity; MIC50: antifungal concentration able to inhibit 50% of all isolates tested; MIC90: antifungal concentration able to inhibit 90% of all isolates tested.