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Summary of EST1 RRM mutants
| EST1 allele | Phenotypea
|
||
|---|---|---|---|
| Viability | Tlc1 RNA binding | Telomere length | |
| Wild type | +++ | +++ | +++ |
| RNP1-NC | −−− | −−− | −−− |
| RNP1-C | +++ | ++ | ++ |
| RNP2-ga | +++ | +++ | +++ |
| RNP2-gs | +++ | + | + |
+++, wild-type behavior; ++ or +, EST1 activity slightly or considerably less than wild-type activity, respectively; −−−, no EST1 activity (i.e., no complementation of an est1 mutant).
