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. 2024 May 9;20(5):e1011253. doi: 10.1371/journal.pgen.1011253

Fig 7. SYD-2 facilitates UNC-104-dependent transport of SVp carriers formed by LRK-1 and the AP-3 complex.

Fig 7

(A) Three hierarchical trafficking steps for formation of SVp carriers and lysosomes. LRK-1 acts with UNC-16 at the Golgi to regulate trafficking of SVp and lysosomal proteins through regulation of the localization of both AP-1 and AP-3 complexes. The question mark LRK-1 and UNC-16 represents a physical interaction between LRK-1 and UNC-16. LRK-1 acts via the AP-3 complex to facilitate formation of the post-Golgi intermediate compartments, SV-lysosomes, from which SVps and lysosomal proteins likely separate into SVp carriers and lysosomes. SYD-2 facilitates UNC-104 dependent transport of SVp carriers into the axon. (B) Schematic representation of SVp carriers and SV-lysosomes formed in different genotypes.