FIG. 8.

Conditional expression of dominant negative Myb in M1 cells using the MT promoter also results in down regulation of c-myc RNA. (A) M1/MTC6+MybEn cells were treated with ZnCl₂ and analyzed for MybEn RNA expression at the indicated times. Induction of MybEn RNA expression was examined by Northern blot analysis using MybEn as a probe. (B) c-myc expression was examined in the same cells by Northern blot analysis at the indicated times after addition of ZnCl₂. Cells transfected with the empty pMTC6+ vector were used as a control. GAPDH was used as a probe to control for loading.