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Inhibition constants for inhibition of chemokine activity by EVA‐ACA1001.
| Chemokine | pIC 50 (M) | IC 50 (nM) |
|---|---|---|
| CCL3 | 7.02 ± 0.12 | 94 |
| CCL4 | 7.07 ± 0.17 | 84 |
| CCL7 | 7.25 ± 0.11 | 55 |
| CCL8 | 6.51 ± 0.11 | 188 |
Note: CCL3, CCL4, and CCL8 signaling at CCR2 and CCL7 signaling at CCR5 were measured as inhibitions of cyclic AMP synthesis. Inhibition constants are reported as pIC 50 = −log(IC 50 , M) ± SEM (n = 3); the corresponding IC 50 values (in nM) are given in parentheses.
