Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Mar 27;149(19):1474–1489. doi: 10.1161/CIRCULATIONAHA.123.067971

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

PMC Copyright notice

Figure 1. — Study design. A randomized, double-blind, isocaloric comparator–controlled cross-over trial in 24 stable patients with heart failure with reduced ejection fraction. Participants underwent a 14-day treatment with oral ketone ester and an isocaloric comparator, after which they were evaluated with right-sided heart catheterization, echocardiography, blood sampling, Kansas City Cardiomyopathy Questionnaire (KCCQ-12), and exercise hemodynamics. Study periods were separated by a 14-day washout period. A 1-day run-in period of each intervention after screening was planned to ensure tolerability before enrollment.