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. Author manuscript; available in PMC: 2025 Mar 1.
Published in final edited form as: Toxicol In Vitro. 2023 Dec 10;95:105762. doi: 10.1016/j.tiv.2023.105762

Table 1.

Number of active PFAS compounds identified for each assay from the set of 136 PFAS compounds tested.

Molecular Initiating Event ≥ 20% activity at highest test concentration ≥ 50% activity at highest test concentration Number with EC50
Human Deiodinase 1 (hDIO1) 28 19 19
Human Deiodinase 2 (hDIO2) 34 18 15
Human Deiodinase 3 (hDIO3) 23 13 11
Xenopus Deiodinase 3 (xDIO3) 24 17 12
Human Iodotyrosine Deiodinase (hIYD) 26 13 11
Xenopus Iodothyronine Deiodinase (xIYD) 19 8 6
Human Thyroid Peroxidase (hTPO) 15 4 3
Human Transthyretin (hTTR) 102 82 76
Human Thyroid Binding Globulin (hTBG) 37 9 7