. Author manuscript; available in PMC: 2025 Mar 1.

Published in final edited form as: Toxicol In Vitro. 2023 Dec 10;95:105762. doi: 10.1016/j.tiv.2023.105762

Table 2.

Compounds active in hDIO1, hDIO2, and hDIO3 assays.

		EC50 (μM)
Name	CASRN	hDIO1	hDIO2	hDIO3	xDIO3
Propylthiouracil (PTU)^a	51-52-5	0.52	nt^c	nt	nt
Xanthohumol^b	6754-58-1	nt	0.221	0.157	0.157
Methyl perfluoro(3-(1-ethenyloxypropan-2-yloxy) propanoate)	63863-43-4	0.37	31.8	3.36	11.1
1H,1H,6H,6H-Perfluorohexane-1,6-diol diacrylate	2264-01-9	5.71	11.2	43.6	15.3
1H,1H,9H-Perfluorononyl acrylate	4180-26-1	9.66	18.4		108.4
1H,1H,5H,5H-Perfluoro-1,5-pentanediol diacrylate	678-95-5	12.4	30.0	104.2	28.4
Perfluorotetradecanoic acid	376-06-7	15.8		29.2
Perfluoroundecanoic acid	2058-94-8	16.9	43.4	24.7
Perfluorotridecanoic acid	72629-94-8	24.7	364	35.4
Perfluoro-3,6,9-trioxatridecanoic acid	330562-41-9	25.6	43.7	22.6	70.0
Perfluorooctanesulfonamide	754-91-6	33.5
1H,1H,5H-Perfluoropentyl methacrylate	355-93-1	42.9	42.2	26.8	32.4
Perfluorohexanesulfonamide	41997-13-1	43.2
Perfluorodecanoic acid	335-76-2	51.1	72.1	70.1	126.4
3,3-Bis(trifluoromethyl)-2-propenoic acid	1763-28-6	70.6
11-H-Perfluoroundecanoic acid	1765-48-6	83.2	51.8	116.6	172.7
((Perfluorooctyl)ethyl)phosphonic acid	8022063-9	169.6
Potassium perfluorooctanesulfonate	2795-39-3	174.0	78.3		145.1
Perfluorooctanesulfonic acid	1763-23-1	184.3	107.5		132.5
9-Chloro-perfluorononanoic acid	865-79-2	218.9	128.7
Perfluorononanoyl chloride	52447-23-1	219.6	331.9
N-Ethylperfluorooctanesulfonamide	4151-50-2		178.8
2,2,3,3-Tetrafluoropropyl acrylate	7383-71-3		154.3
Perfluorooctanesulfonyl fluoride	307-35-7			215.1
2-(Perfluorobutyl)ethyl acrylate	52591-27-2				70.3

Model positive control compound for inhibition of DIO1 activity.

Model positive control compound for inhibition of DIO2 and DIO3 activity.

nt = not tested.