Table 2. Signal detection methods and thresholds to be evaluated.

Signal detection method	Signal detection algorithm*	Threshold†
Abbreviation: PRR=proportional reporting ratio; ROR=reporting odds ratio; BCPNN=Bayesian confidence propagation neural network; MGPS=multi-item gamma Poisson shrinker; CI=confidence interval; IC=information component; EBGM=empirical Bayesian geometric mean. * The number refers to various thresholds. † The variable “a” represents the number of reports that include both the specific vaccine being studied and the AEFI being investigated.
PRR	PRR1	Lower limit of 95% CI of PRR > 1(7) and a ≥ 3
	PRR2	Lower limit of 95% CI of PRR > 1(7) and a ≥ 5
	PRR3	PRR > 2 and χ2 ≥ 4 and a ≥ 3 (7)
ROR	ROR1	Lower limit of 95% CI of ROR > 1 and a ≥ 3 (7,12)
	ROR2	Lower limit of 95% CI of ROR > 1 and a ≥ 5 (12)
BCPNN	BCPNN	Lower limit of 95% CI of IC > 0 (12)
MGPS	MGPS1	5th percentile of EBGM (EB05) > 2 (7)
	MGPS2	5th percentile of EBGM (EB05) ≥ 1.8 and EBGM ≥ 2.5 (12)
	MGPS3	EBGM ≥ 2 (7,13)