Table 7.

Spearman rank-test correlation coefficients (r_s) inter-ASVs.

Genus	Bifidobacterium	Escherichia-Shigella	Alloprevotella	Collinsella	Peptostreptococcus	Prevotella	Prevotella_9	Ligilactobacillus	Phascolarctobacterium	ASV 25	Prevotella_7	Lachnospiraceae UCG-004	Faecalicoccus	ASV 58	Erysipelatoclostridium	Desulfovibrio	Akkermansia	Flavonifractor	ASV 91	Allisonella	Dialister	Lachnospiraceae FCS020 group	Intestinibacter	Butyricimonas
Bifidobacterium	NS	−0.35*	−0.50**	0.58***	−0.45**	−0.47**	NS	−0.53***	−0.28	−0.36*	0.62***	NS	0.56***	0.39*	0.31	NS	0.33	0.52***	NS	NS	0.52***	0.32	0.42*	NS
Escherichia-Shigella	−0.35*	NS	NS	−0.31	0.52***	NS	NS	NS	NS	NS	−0.49**	NS	−0.41*	−0.38*	−0.30	NS	NS	−0.43**	−0.39*	NS	−0.32	−0.44**	NS	NS
Alloprevotella	−0.50**	NS	NS	NS	0.43*	0.57***	0.64***	0.58***	0.63***	0.71***	−0.58***	0.36*	−0.60***	−0.58***	−0.49**	−0.28	−0.68***	−0.45**	−0.39*	0.35*	−0.40*	NS	−0.61***	−0.35*
Collinsella	0.58***	−0.31	NS	NS	−0.29	NS	NS	−0.41*	NS	NS	0.40*	NS	0.29	0.33	NS	NS	NS	0.39*	NS	NS	NS	NS	NS	NS
Peptostreptococcus	−0.45**	0.52***	0.43*	−0.29	NS	0.43**	NS	0.42*	NS	NS	−0.61***	NS	−0.52***	−0.67***	−0.30	NS	−0.43*	−0.63***	−0.66***	0.46**	−0.33	−0.70***	−0.37*	−0.34*
Prevotella	−0.47**	NS	0.57***	NS	0.43**	NS	0.34*	0.36*	0.36*	0.51***	−0.62***	NS	−0.59***	−0.39*	−0.28	NS	−0.50**	NS	−0.27	NS	−0.40*	−0.27	−0.64***	NS
Prevotella_9	NS	NS	0.64***	NS	NS	0.34*	NS	0.77***	0.45**	0.74***	−0.39*	NS	−0.55***	−0.41*	−0.35*	NS	NS	NS	NS	NS	NS	NS	−0.29	NS
Ligilactobacillus	−0.53***	NS	0.58***	−0.41*	0.42*	0.36*	0.77***	NS	0.49***	0.61***	−0.54***	NS	−0.61***	−0.46**	−0.36*	NS	−0.50**	−0.30	NS	0.30	−0.42*	NS	−0.37*	NS
Phascolarctobacterium	−0.28	NS	0.63***	NS	NS	0.36*	0.45**	0.49***	NS	0.62***	−0.33	0.39*	NS	NS	NS	NS	−0.42*	NS	NS	NS	−0.44**	NS	−0.38*	NS
ASV 25	−0.36*	NS	0.71***	NS	NS	0.51***	0.74***	0.61***	0.62***	NS	−0.40*	NS	−0.59***	−0.34*	−0.37*	NS	−0.64***	NS	NS	NS	−0.29	NS	−0.39*	NS
Prevotella_7	0.62***	−0.49**	−0.58***	0.40*	−0.61***	−0.62***	−0.39*	−0.54***	−0.33	−0.40*	NS	NS	0.69***	0.61***	0.41*	NS	0.44**	0.56***	0.57***	−0.29	0.70***	0.55***	0.33	NS
Lachnospiraceae UCG-004	NS	NS	0.36*	NS	NS	NS	NS	NS	0.39*	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	0.32	NS	NS	NS
Faecalicoccus	0.56***	−0.41*	−0.60***	0.29	−0.52***	−0.59***	−0.55***	−0.61***	NS	−0.59***	0.69***	NS	NS	0.62***	0.42*	0.41*	0.62***	0.50**	0.29	−0.33	0.48**	0.42*	0.49**	0.47**
ASV 58	0.39*	−0.38*	−0.58***	0.33	−0.67***	−0.39*	−0.41*	−0.46**	NS	−0.34*	0.61***	NS	0.62***	NS	0.29	0.32	0.52***	0.52***	0.50**	−0.52***	0.37*	0.55***	0.39*	0.49**
Erysipelatoclostridium	0.31	−0.30	−0.49**	NS	−0.30	−0.28	−0.35*	−0.36*	NS	−0.37*	0.41*	NS	0.42*	0.29	NS	0.35*	0.36*	0.43**	NS	NS	0.29	0.38*	0.51***	0.31
Desulfovibrio	NS	NS	−0.28	NS	NS	NS	NS	NS	NS	NS	NS	NS	0.41*	0.32	0.35*	NS	0.41*	NS	NS	NS	NS	NS	NS	0.75***
Akkermansia	0.33	NS	−0.68***	NS	−0.43*	−0.50**	NS	−0.50**	−0.42*	−0.64***	0.44**	NS	0.62***	0.52***	0.36*	0.41*	NS	NS	NS	NS	0.36*	NS	0.48**	0.41*
Flavonifractor	0.52***	−0.43**	−0.45**	0.39*	−0.63***	NS	NS	−0.30	NS	NS	0.56***	NS	0.50**	0.52***	0.43**	NS	NS	NS	0.60***	−0.51***	0.31	0.71***	0.41*	0.39*
ASV 91	NS	−0.39*	−0.39*	NS	−0.66***	−0.27	NS	NS	NS	NS	0.57***	NS	0.29	0.50**	NS	NS	NS	0.60***	NS	−0.37*	0.33	0.74***	0.30	NS
Allisonella	NS	NS	0.35*	NS	0.46**	NS	NS	0.30	NS	NS	−0.29	0.32	−0.33	−0.52***	NS	NS	NS	−0.51***	−0.37*	NS	NS	−0.43**	−0.38*	−0.31
Dialister	0.52***	−0.32	−0.40*	NS	−0.33	−0.40*	NS	−0.42*	−0.44**	−0.29	0.70***	NS	0.48**	0.37*	0.29	NS	0.36*	0.31	0.33	NS	NS	0.32	0.39*	NS
Lachnospiraceae FCS020 group	0.32	−0.44**	NS	NS	−0.70***	−0.27	NS	NS	NS	NS	0.55***	NS	0.42*	0.55***	0.38*	NS	NS	0.71***	0.74***	−0.43**	0.32	NS	NS	NS
Intestinibacter	0.42*	NS	−0.61***	NS	−0.37*	−0.64***	−0.29	−0.37*	−0.38*	−0.39*	0.33	NS	0.49**	0.39*	0.51***	NS	0.48**	0.41*	0.30	−0.38*	0.39*	NS	NS	0.28
Butyricimonas	NS	NS	−0.35*	NS	−0.34*	NS	NS	NS	NS	NS	NS	NS	0.47**	0.49**	0.31	0.75***	0.41*	0.39*	NS	−0.31	NS	NS	0.28	NS

NS, Not statistically significant (P > 0.05); No annotation, P ≤ 0.05. ^*P ≤ 0.01. ^**P ≤ 0.001. ^***P ≤ 0.0001.