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. 2000 Mar;20(6):2108–2121. doi: 10.1128/mcb.20.6.2108-2121.2000

FIG. 5.

FIG. 5

Similarity of the cysteine-rich regions of hCGBP (Hu-CGBP) to conserved motifs. (A) Alignment of hCGBP PHD1 domain (aa 27 to 73) and sequences with highest degrees of similarity. Ye_EST1 and Ye_EST2 (EST clones AL031523 and AL031852, respectively), S. pombe putative transcriptional regulatory proteins of PHD finger family; Ce_EST1, C. elegans EST clone Z81515; Hu_EST1, human EST clone AF044076; p33ING1, candidate tumor suppressor; Hu_EST2, human EST clone AL031852; Hu_RBB2, human retinoblastoma binding protein 2; Dr_PCL_B, Drosophila polycomb-like protein. (B) Alignment of hCGBP PHD2 domain (aa 485 to 591) and sequences with highest degrees of similarity: Dr_EST, putative Drosophila homologue of hCGBP (EST clone AI404379); Hu_EST3, human EST clone AL009172; Ce_EST2, C. elegans EST clone Z82268; Hu_HRX, human trithorax protein (27, 55); and Dr_TRX, Drosophila trithorax protein (36). (C) Alignment of hCGBP CXXC domain (aa 164 to 208) and sequences with highest levels of similarity: MBD1 (MBD1a, aa 174 to 218; MBD1b, aa 223 to 265; MBD1c, aa 336 to 379) (23), HRX (27, 32, 55), and DNMT (DNA methyltransferase) (7). (D) Alignment of hCGBP (aa 374 to 547) with putative Drosophila homologue (Dr_EST; EST clone AI404379) (aa 19 to 190). In all panels, identical amino acids are boxed.