Figure 8.
5-ethynyl-2’-deoxyuridine (EdU) proliferation assay images and the number of EdU+ cells after 6 hours of jejunal and ileal CS or NMP. (A) EdU (purple) whole mount immunofluorescence on jejunal and ileal T0, CS-T6, and NMP-T6 spheroids. (B) NMP-T6 jejunal and ileal spheroids contained a great number of EdU+ cells compared with T0 or CS-T6. T0 = 10 pigs, CS-T6 = 7 pigs, and NMP-T6 = 8 pigs. Original magnification: 20×, scale bar: 50 μm. *P ≤.05, **P ≤.01, ***P ≤.001, and ****P ≤.0001. CS, cold storage; CS-T6, 6 hours of cold storage; NMP, normothermic machine perfusion; NMP-T6, 6 hours of normothermic machine perfusion; T0, control tissue.