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. 2024 Apr 18;124(9):5668–5694. doi: 10.1021/acs.chemrev.3c00752

Table 2. Examples of Protein Desiccation in Glassy Matrices and Aerogels.

Matrix composition Matrix type Embedded proteins Refs
amorphous SiO2 sol–gels, sol–gels plus additives lysozyme, α-lactalbumin, hemoglobin, metmyoglobin, creatine kinase, hexokinase, heme proteins, glucose oxidase, peroxidases, catalase, tyrosinase, lactate dehydrogenase, urease, bovine carbonic anhydrase, alkaline phosphatase, acetylcholinesterase, butyrylcholinesterase, acid phosphatase, xylanase (8795,101103)
amorphous SiO2 aerogel glucose oxidase, acid phosphatase, xylanase (95)
Au-immobilized protein in SiO2 aerogel cytochrome c (104)
sucrose, trehalose, and leucine sprayed or lyophilized glass lysozyme, rubella vaccine, and influenza antigen (105108)
sucrose, glycerol, maltose, maltodextrin, sorbitol, 1,6-anhydroglucose, and trehalose freeze-dried glass igG1, monoclonal antibody, cytokines, pepsin, plasma components, trypsin lysozyme and catalase (109114)
trehalose convective air drying whey protein (115)
micelles/reverse micelles zwitterionic surfactants, block copolymers cytochrome c, laccase spore coat protein A (116,117)