Table 2.
Distribution of microvascular invasion and tumour characteristics per intensity of des-γ-carboxy prothrombin labelling in liver lesions of hepatocellular carcinoma.
| All Lesions (n = 119) | Negative Labelling (n = 58) | Focally Positive Labelling (n = 27) | Diffusely Positive Labelling (n = 34) | p a | |
|---|---|---|---|---|---|
| Medians (IQR) or n (%) | |||||
| Maximum diameter (mm) | 12 (9–21) | 12 (7–18) | 12 (8–18) | 20 (12–26) | 0.002 b |
| Microvascular invasion (presence) | 44 (37.0) | 11 (19.0) | 13 (48.1) | 20 (58.8) | <0.001 |
| Differentiation | |||||
| No tumour residue | 20 (16.8) | 20 (34.5) | 0 (0.0) | 0 (0.0) | <0.001 |
| Low-grade dysplasia | 2 (1.7) | 2 (3.4) | 0 (0.0) | 0 (0.0) | 0.343 |
| High-grade dysplasia | 1 (0.8) | 1 (1.7) | 0 (0.0) | 0 (0.0) | 0.588 |
| Well-differentiated tumour | 17 (14.3) | 12 (20.7) | 3 (11.1) | 2 (5.9) | 0.127 |
| Moderately differentiated tumour | 65 (54.6) | 17 (29.3) | 21 (77.8) | 27 (79.4) | <0.001 |
| Poorly differentiated tumour | 10 (8.4) | 5 (8.6) | 3 (11.1) | 2 (5.9) | 0.763 |
| Features of CCC or mixed HCC-CCC | 4 (3.4) | 1 (1.7) | 0 (0.0) | 3 (8.8) | 0.103 |
The values of p that are statistically significant are reported in bold. a Kruskal–Wallis tests for quantitative variables and Χ2 tests for nominal variables; b Dunn’s multiple comparisons test for negative labelling vs. diffusely positive labelling p = 0.003 and for focally positive labelling vs. diffusely positive labelling p = 0.023. Abbreviations: CCC, cholangiocellular carcinoma; HCC, hepatocellular carcinoma.