Figure 2.

Potential molecular changes driving medulloblastoma progression and relapse. Primary medulloblastoma (MB) subgroups with highlighted molecular drivers and proposed cells of origin are shown [21]. Risk factors state molecular markers associated with relapse. Molecular markers listed in the relapse column have been described in tumors samples at relapse. The last column also states localization of relapse dependent on subgroup. WNT: WNT-activated, SHH: Sonic hedgehog activated, G3: non-WNT/non-SHH Group 3. G4: non-WNT/non-SHH Group 4. LRL: lower rhombic lip, GPC granular precursor cell, Photo^Sig: Photoreceptor signature, UBC^Sig: unipolar brush cell signature. Mut: mutated, Amp: amplified, Act: activated, Pos: positive.