Figure 2.

Illustration of the DP-Immunoscore calculation method. (A) Densities of CD3+ and CD8+ at both CT and IM are converted into percentile values. The mean percentile of the four markers is calculated and represented into a five-category (IS0, IS1, IS2, IS3, IS4) or a three- (IS-Low, IS-Int, IS-High) or a two-category scoring system (IS-Low, IS-High). Based on measuring immune response at the tumor site, IS predicts the risk of relapse in localized colon cancer to identify patients who could be spared from chemotherapy. (B) Ring charts illustrating the relative contribution of each risk parameter to recurrence risk in patients with stages II and II/III colon cancer. IS (red) is the highest predictor of time to recurrence (TTR) in both subgroups.