TABLE 2.
Linear association (left) and two-sample MR analysis (right) results
| Linear association | MR analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| BP | Group | Beta estimate | Lower 95% CI | Upper 95% CI | BH-adjusted P value | Standardized estimate | Lower 95% CI | Upper 95% CI | P value |
|
| |||||||||
| Without stratification | |||||||||
| SBP | Whole | 0.0120 | 0.0083 | 0.0156 | 4.30E-10*** | −0.0048 | −0.0234 | 0.0137 | 6.09E-01 |
| DBP | 0.0175 | 0.0111 | 0.0239 | 1.31E-07 *** | 0.0371 | 0.0034 | 0.0709 | 3.11E-2 * | |
| With age stratification | |||||||||
| SBP | 40–49 | 0.0070 | −0.0016 | 0.0156 | 1.64E-01 | −0.0460 | −0.0860 | −0.0060 | 2.44E-2 * |
| DBP | 0.0117 | −0.0013 | 0.0246 | 1.18E-01 | 0.0069 | −0.0539 | 0.0676 | 8.25E-01 | |
| SBP | 50–59 | 0.0163 | 0.0103 | 0.0223 | 3.74E-07 *** | −0.0002 | −0.0290 | 0.0287 | 9.91E-01 |
| DBP | 0.0259 | 0.0154 | 0.0364 | 5.54E-06 *** | 0.0151 | −0.0357 | 0.0659 | 5.60E-01 | |
| SBP | 60–69 | 0.0086 | 0.0032 | 0.0140 | 4.25E-03 ** | 0.0230 | −0.0099 | 0.0559 | 1.70E-01 |
| DBP | 0.0147 | 0.0048 | 0.0246 | 7.11E-03 ** | 0.0991 | 0.0414 | 0.1568 | 7.68E-04 *** | |
| With sex stratification | |||||||||
| SBP | Female | 0.0149 | 0.0100 | 0.0197 | 7.38E-09 *** | 0.0112 | −0.0130 | 0.0355 | 3.64E-01 |
| DBP | 0.0233 | 0.0146 | 0.0319 | 3.59E-07 *** | 0.0484 | 0.0062 | 0.0905 | 2.45E-02 * | |
| SBP | Male | 0.0074 | 0.0017 | 0.0131 | 2.05E-02 * | −0.0281 | −0.0635 | 0.0073 | 1.20E-01 |
| DBP | 0.0094 | −0.0001 | 0.0189 | 9.54E-02 ~. | 0.0297 | −0.0293 | 0.0887 | 3.24E-01 | |
| With age by sex stratification | |||||||||
| SBP | 40–49 female | 0.0053 | −0.0056 | 0.0161 | 3.44E-01 | −0.0529 | −0.0983 | −0.0075 | 2.23E-02 * |
| DBP | 0.0095 | −0.0075 | 0.0265 | 2.75E-01 | −0.0139 | −0.0893 | 0.0615 | 7.17E-01 | |
| SBP | 40–49 male | −0.0004 | −0.0150 | 0.0141 | 9.54E-01 | −0.0495 | −0.1222 | 0.0231 | 1.81E-01 |
| DBP | 0.0072 | −0.0139 | 0.0283 | 5.04E-01 | 0.0201 | −0.0781 | 0.1184 | 6.88E-01 | |
| SBP | 50–59 female | 0.0153 | 0.0077 | 0.0228 | 7.36E-05 *** | 0.0329 | −0.0029 | 0.0688 | 7.18E-02 ~. |
| DBP | 0.0352 | 0.0212 | 0.0492 | 8.91E-07 *** | 0.0686 | 0.0054 | 0.1318 | 3.35E-02 * | |
| SBP | 50–59 male | 0.0125 | 0.0027 | 0.0223 | 1.24E-02 * | −0.0438 | −0.0986 | 0.0109 | 1.17E-01 |
| DBP | 0.0127 | −0.0035 | 0.0288 | 1.24E-01 | −0.0441 | −0.1245 | 0.0363 | 2.83E-01 | |
| SBP | 60–69 female | 0.0114 | 0.0038 | 0.0190 | 3.46E-03 ** | 0.0137 | −0.0263 | 0.0537 | 5.01E-01 |
| DBP | 0.0177 | 0.0034 | 0.0319 | 1.50E-02 * | 0.0962 | 0.0209 | 0.1714 | 1.22E-02* | |
| SBP | 60–69 male | 0.0007 | −0.0070 | 0.0085 | 8.51E-01 | 0.0289 | −0.0214 | 0.0793 | 0.2602 |
| DBP | 0.0104 | −0.0037 | 0.0246 | 1.47E-01 | 0.0949 | −0.0029 | 0.1926 | 5.71E-02 ~. | |
Multiple potential confounders are adjusted in both models. Results for both overall analysis (i.e. without stratification) and stratified analysis by age and sex are shown.
~.
P < 0.1.
*
P < 0.05.
**
P < 0.01.
***
P < 0.001.