Table 3.
Univariable and multivariable analysis of clinicopathologic factors on survival before and after group stratification.
| Univariable | Multivariable * | |||||
|---|---|---|---|---|---|---|
| Before Group Stratification | After Group Stratification | |||||
| Variable | HR (%95 CI) | p | HR (%95 CI) | p | HR (%95 CI) | p |
| Age (years) | 0.76 (0.47–1.19) | 0.24 | 0.78 (0.43–1.39) | 0.4 | 0.68 (0.38–1.21) | 0.2 |
| ≤65 | ||||||
| >65 | ||||||
| CEA (ng/mL) | 1.21 (0.74–1.94) | 0.44 | 1.24 (0.72–2.09) | 0.42 | 1.39 (0.79–2.41) | 0.24 |
| ≤5 | ||||||
| >5 | ||||||
| Number of lesions | 1.19 (0.77–1.85) | 0.44 | 0.92 (0.49–1.75) | 0.8 | 0.98 (0.52–1.86) | 0.94 |
| ≤4 | ||||||
| >4 | ||||||
| Diameter largest lesion (cm) | 0.77 (0.49–1.2) | 0.25 | 1.14 (0.63–2.1) | 0.67 | 0.99 (0.56–1.78) | 0.99 |
| ≤3 | ||||||
| >3 | ||||||
| Distribution of lesions | ||||||
| Bilobar | 1.19 (0.74–1.92) | 0.48 | 1.03 (0.48–2.1) | 0.99 | 0.84 (0.41–1.79) | 0.64 |
| Location of colon primary | ||||||
| Right | 1.53 (0.96–2.44) | 0.07 | 0.72 (0.42–1.2) | 0.22 | 0.79 (0.46–1.4) | 0.39 |
| Presentation of metastasis | ||||||
| Synchronous | 1.01 (0.57–1.77) | 0.98 | 1.2 (0.44–3) | 0.69 | 1.45 (0.52–3.6) | 0.44 |
| Perioperative chemotherapy | ||||||
| Received | 1.05 (0.33–3.37) | 0.93 | 0.97 (0.22–3) | 0.97 | 0.94 (0.21–2.92) | 0.92 |
| Never debulked group | Reference | Reference | ||||
| Partial debulked group | 0.48 (0.27–0.85) | 0.01 | 0.56 (0.29–1.03) | 0.08 | ||
| Subtotal debulked group | 0.42 (0.23–0.77) | 0.005 | 0.37 (0.17–0.8) | 0.01 | ||
| Combined partial + subtotal debulked group | 0.46 (0.28–0.76) | 0.002 | 0.48 (0.27–0.9) | 0.02 | ||
HR, hazard ratio; BMI, body mass index; CEA, carcinoembryonic antigen. * Analysis was performed with the “never debulked” group as the reference group.