Table 3.
Univariate logistic regression of association between CYP7B1 and clinical and pathological variables in the whole cohort.
| Positive Expression of CYP7B1 | p-Value | |
|---|---|---|
| Age, OR (CI) | 1.00 (0.97–1.04) | 0.8 |
| PSA, OR (CI) | 1.01 (0.99–1.03) | 0.3 |
| Fasting glucose, OR (CI) | 1.00 (0.99–1.02) | 0.6 |
| Total cholesterol, OR (CI) | 1.00 (0.99–1.01) | 0.6 |
| Triglycerides, OR (CI) | 1.00 (0.99–1.00) | 0.7 |
| Diabetes, OR (CI) | 0.91 (0.47–1.74) | 0.8 |
| Ki-67-positive score, OR (CI) | 0.91 (0.49–1.67) | 0.8 |
| AR-positive score, OR (CI) | 1.36 (0.85–2.17) | 0.2 |
| PSMA-positive score, OR (CI) | 1.66 (1.04–2.66) | 0.03 |
| IR-α-positive score, OR (CI) | 5.73 (2.77–11.84) | <0.01 |
| IR-β-positive score, OR (CI) | 6.61 (2.19–19.96) | <0.01 |
| IGF-1R-positive score, OR (CI) | 0.93 (0.53–1.63) | 0.8 |
| ATPLy-positive score, OR (CI) | 3.73 (2.40–5.79) | <0.01 |
| SRSF-1-positive score, OR (CI) | 2.04 (1.27–3.29) | <0.01 |
| CPT1-a-positive score, OR (CI) | 1.33 (0.74–2.41) | 0.3 |
| SCD-1-positive score, OR (CI) | 1.22 (0.67–2.21) | 0.5 |
| SREBP1-positive score, OR (CI) | 0.61 (0.35–1.06) | 0.08 |
| FAS-positive score, OR (CI) | 2.15 (1.28–3.62) | <0.01 |
| ACC-1-positive score, OR (CI) | 1.83 (1.14–2.93) | 0.01 |
OR = odds ratio; CI = confidence interval; CYP7B1 = cytochrome 7B1; AR = androgenic receptor; PSA = prostate-specific antigen; IR = insulin receptor; IGF-1R = insulin-like growth factor-1 receptor; PSMA = prostate-specific membrane antigen; SRSF-1 = serine/arginine-rich splicing factor 1; FAS = fatty acid synthase; CPT-1a = carnitine palmitoyltransferase 1a; SCD-1 = stearoyl-CoA desaturase-1; SREBP-1 = sterol regulatory element-binding protein-1; ACC-1 = acetyl-CoA carboxylase-1.