Table 2.
Correlation between SKP2 expression, Lack of both p21 and p27 in tumor cells, with clinicopathological parameters of 74 breast cancer patients
| SKP2 (≥ 10%) | *p | DN p27/p21 (− both, + if either) | *p | |||
|---|---|---|---|---|---|---|
| − | + | − | + | |||
| Age | ||||||
| < 40 years | 14 (58) | 10 (42) | 0.432 | 10 (42) | 14 (58) | 1.00 |
| ≥ 40 years | 35 (70) | 15 (30) | 21 (42) | 29 (58) | ||
| Tumor size | ||||||
| < 4 cm | 26 (65) | 14 (35) | 1.00 | 15 (38) | 25 (62) | 0.481 |
| ≥ 4 cm | 23 (68) | 11 (32) | 16 (47) | 18 (53) | ||
| Invasion | ||||||
| Absent | 19 (63) | 11 (37) | 0.803 | 11 (37) | 19 (63) | 0.482 |
| Present | 30 (68) | 14 (32) | 20 (45) | 24 (55) | ||
| Histological grade | ||||||
| 1 & 2 | 33 (89) | 4 (11) | < 0.001 | 11 (30) | 26 (70) | 0.059 |
| 3 | 16 (43) | 21 (57) | 20 (54) | 17 (46) | ||
| Lymph node metastasisa | ||||||
| Absent | 15 (60) | 10 (40) | 0.442 | 11 (44) | 14 (56) | 1.00 |
| Present | 32 (70) | 14 (30) | 19 (41) | 27 (59) | ||
| ER status | ||||||
| Negative | 10 (34) | 19 (66) | < 0.001 | 18 (62) | 11 (38) | 0.008 |
| Positive | 39 (87) | 6 (13) | 13 (29) | 32 (71) | ||
| PR status | ||||||
| Negative | 22 (52) | 20 (48) | 0.006 | 20 (48) | 22 (52) | 0.342 |
| Positive | 27 (84) | 5 (16) | 11 (34) | 21 (66) | ||
| Her2/neu | ||||||
| Negative | 36 (72) | 14 (28) | 0.189 | 20 (40) | 30 (60) | 0.802 |
| Positive | 13 (54) | 11 (46) | 11 (46) | 13 (54) | ||
| PD-L1 | ||||||
| < 5% | 47 (78) | 13 (22) | < 0.001 | 19 (32) | 41 (68) | < 0.001 |
| ≥ 5% | 2 (14) | 12 (86) | 12 (86) | 2 (14) | ||
| Ki-67 | ||||||
| ≤ 20% | 37 (88) | 5 (12) | < 0.001 | 11 (26) | 31 (74) | 0.002 |
| > 20% | 12 (38) | 20 (62) | 20 (63) | 12 (37) | ||
| Vimentin | ||||||
| Negative | 42 (82) | 9 (18) | < 0.001 | 16 (31) | 35 (69) | 0.010 |
| Positive | 7 (30) | 16 (70) | 15 (65) | 8 (35) | ||
| E-Cadherin | ||||||
| Present | 41 (79) | 11 (21) | < 0.001 | 22 (42) | 30 (58) | 1.00 |
| Lost | 8 (36) | 14 (64) | 9 (41) | 13 (59) | ||
| Vimentin & loss E-Cadherin | ||||||
| Negative | 47 (76) | 15 (24) | < 0.001 | 24 (38) | 38 (62) | 0.223 |
| Positive | 2 (17) | 10 (83) | 7 (58) | 5 (42) | ||
DN Double negative
*(+ and −) are the number of positive and negative patients, the numbers between brackets are the percentages of patients, and ⋄ p values in bold and highlighted represent significant data
aThree cases with unknown LN involvement