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TLRs in infection and inflammation.
| Role | Mechanisms | Implications |
|---|---|---|
| Innate Immunity | Recognize PAMPs and DAMPs, initiate signaling cascades | First line of defense against pathogens |
| Adaptive Immunity | Activate dendritic cells, modulate T cell responses | Bridge innate and adaptive immunity |
| Inflammatory Diseases | Aberrant TLR signaling, persistent activation | Autoimmunity, chronic inflammation |
| Cancer | Dual role in tumor progression and anti-tumor immunity | Potential therapeutic targets |
