Table 2.
AChE and COX-2 inhibition percentages (%) of EVOO extracts.
| AChE | COX-2 | |||
|---|---|---|---|---|
| Sample a | PDO | Variety | % Inhibition | % Inhibition |
| 1 | PG | Hojiblanca | 74.80 ± 7.12 b | 63.26 ± 1.55 cde |
| 2 | PG | Picudo | 75.04 ± 2.10 b | 59.76 ± 2.37 ef |
| 3 | MG | Picual | 73.09 ± 1.42 b | 62.50 ± 1.00 cdef |
| 4 | PG | Chorreao | 86.82 ± 0.36 a | 63.63 ± 1.97 cde |
| 5 | PG | Hojiblanca | 54.99 ± 5.05 e | 54.58 ± 3.46 gh |
| 6 | PG | Manzanillo | 87.21 ± 1.89 a | 66.86 ± 0.84 bc |
| 7 | PG | Picudo | 85.10 ± 1.89 a | 64.42 ± 1.12 bcd |
| 8 | PG | Chorreao | 77.85 ± 4.20 b | 65.69 ± 4.29 bcd |
| 9 | MG | Picual | 86.43 ± 1.83 a | 68.48 ± 3.02 b |
| 10 | PG | Hojiblanca | 63.65 ± 2.39 cd | 53.04 ± 5.45 h |
| 11 | PG | Hojiblanca | 58.89 ± 1.29 de | 58.43 ± 4.45 fg |
| 12 | MG | Picual | 67.00 ± 0.94 c | 61.75 ± 1.34 def |
| 13 | MG | Picual | 20.75 ± 0.49 g | 58.89 ± 0.63 fg |
| 14 | MG | Coupage | 46.02 ± 4.81 f | 64.06 ± 1.48 cde |
| 15 | PG | Picual | 45.63 ± 3.16 f | 65.46 ± 1.02 bcd |
| Celecoxib | - | - | - | 87.02 ± 1.10 a |
| Physostigmin | - | - | 48.52 ± 1.69 f | - |
PDO, Protective Denomination of Origin; PG, Poniente de Granada; MG, Montes de Granada; Coupage: mix of Picual, Arbequina, and Hojiblanca. Different letters in the same column indicate significant differences (p < 0.05, Kruskal-Wallis test) between the percentage inhibition of EVOO samples. a In the AChE inhibition assay, the bioactive compounds extracted from 0.150 g of EVOO and 0.025 µM of physostigmin were present in 250 μL of medium reaction containing 2.5 mU of AChE; in the COX-2 inhibition assay, the bioactive compounds extracted from 0.625 mg of EVOO and 0.050 µM of celecoxib were present in 100 μL of medium reaction.