Table 2.
Properties of mechano-gated channels.
| Permeability (P) | Mechanical Sensitivity | Erev | References | |
|---|---|---|---|---|
| BK | Permeable to K+ | Membrane tension | EK: −75 to −90 mV | [13] |
| TRAAK | Permeable to K+ | Membrane tension | EK: −75 to −90 mV | [14,15,16,17] |
| TREK1, TREK2 | Permeable to K+ | Membrane stretch | EK: −75 to −90 mV | [16] |
| Piezo1, Piezo2 | Permeable to monovalent and divalent cations | Membrane stretch, touch | −15 to 0 mV | [18,19,20,21,22,23] |
| ENaCa | PNa:PK = 100:1 | Membrane stretch | −10 to 0 mV | [24,25,26] |
| TRPV2 | PCa: PNa = 2.8 | Mechanical and osmotic pressure, membrane stretch, heat > 52 °C | −3 to 10 mV | [15,27,28,29] |
| TRPV4 | PCa: PNa = 6 to 10 | Mechanical and osmotic pressure, touch, heat 27–34 °C | −10 to 0 mV | [30,31,32,33,34,35,36] |
| TRPV1 | PCa: PNa = 10 | Heat 43 to 50 °C Pressure-sensitive or -insensitive |
~0 mV | [27,37,38,39] |
| TRPA1, TRPC1/3/5/6, TRPM3/4/7, TRPP1/2 | PCa > PNa: TRPC5 (8), TRPM7 (3), TRPM3α2 (1.5) PCa < PNa: TRPA1 (0.8), TRPM4/5 (~0.01), TRPM3α1 (0.1), TRPP2 (4) |
Mechanosensitive | ~0 mV | [22,40,41] |