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. 2024 May 1;25(9):4956. doi: 10.3390/ijms25094956

Figure 2.

Figure 2

TTP/DIC index. In patients where there is difficulty differentiating between TTP or DIC, factor XIII activity and haptoglobin can be measured to obtain an index by subtracting haptoglobin (mg/dL) from FXIII activity (%). If the index is ≥60, TTP is clinically suspected. If the index is <60, DIC is clinically suspected. FXIII activity alone or haptoglobin alone are also useful for distinguishing between TTP and DIC. The cutoff level of haptoglobin is 2.868 mg/dL, above which DIC is suspected and below which TTP is suspected (AUC 0.832 (95% confidence interval, 0.727–0.938)). The cut-off level of factor XIII activity is 76.0%, above which TTP is suspected and below which DIC is suspected (AUC 0.931 (95% confidence interval, 0.873–0.989)) [118]. Abbreviations: TTP, thrombotic thrombocytopenic purpura; DIC, disseminated intravascular coagulation; AUC, area under the curve.