Table 2.
Comparison of DIC diagnostic criteria.
| Criteria | JMHLW | ISTH | JAAM | JSTH | ||
|---|---|---|---|---|---|---|
| Basic | Hematopoietic Disorder | Infectious | ||||
| Platelet count (×104/μL) |
≤12 + 1 pt ≤8 + 2 pt ≤5 + 3 pt |
≤10 + 1 pt ≤5 + 2 pt |
≤12 + 1 pt ≤8 + 3 pt >30% reduction/24 h + 1 pt >50% reduction/24 h + 3 pt |
>8, ≤12 + 1 pt >5, ≤8 + 2 pt ≤5 + 3 pt ≥30% decrease/24 h + 1 pt |
- | >8, ≤12 + 1 pt >5, ≤8 + 2 pt ≤5 + 3 pt ≥30% decrease/24 h + 1 pt |
| PT ratio | ≥1.25 + 1 pt ≥1.67 + 2 pt |
- | ≥1.2 + 1 pt | ≥1.25, <1.67 + 1 pt ≥1.67 + 2 pt |
||
| PT (s) | - | Prolonged PT ≥3 s + 1 pt ≥6 s + 2 pt |
- | - | ||
| Fibrinogen (mg/dL) | ≤150 + 1 pt ≤100 + 2 pt |
≤100 + 1 pt | - | >100, ≤150 + 1 pt ≤100 + 2 pt |
- | |
| FDP (μg/mL) | ≥10 + 1 pt ≥20 + 2 pt ≥40 + 3 pt |
≥10 + 2 pt ≥25 + 3 pt |
≥10 + 1 pt ≥25 + 3 pt |
≥10, <20 + 1 pt ≥20, <40 + 2 pt ≥40 + 3 pt |
||
| Antithrombin (%) | - | - | - | ≤70% + 1 pt | ||
| TAT, SF, F1 + 2 | - | - | - | ≥2-fold upper limit of normal + 1 pt | ||
| SIRS | - | - | ≥3 + 1 pt | - | ||
| Underlying diseases | +1 pt | - | - | - | ||
| Bleeding | +1 pt | - | ||||
| Organ failure | +1 pt | |||||
| Liver failure | - | - | - | Yes -3 pt | ||
| Diagnosis of DIC | ≥7 pt | ≥5 pt | ≥4 pt | ≥6 pt | ≥4 pt | ≥5 pt |
Abbreviations: DIC, disseminated intravascular coagulation; PT, prothrombin time; FDP, fibrin/fibrinogen degradation products; TAT, thrombin–antithrombin complex; SF, soluble fibrin; F1 + 2, prothrombin fragment 1 + 2; SIRS, systemic inflammatory response syndrome; JMHLW, Japanese Ministry of Health, Labour and Welfare; ISTH, International Society on Thrombosis and Haemostasis; JAAM, Japanese Association of Acute Medicine; JSTH, Japanese Society on Thrombosis and Hemostasis.