Skip to main content
. 2024 Apr 29;25(9):4853. doi: 10.3390/ijms25094853

Figure 1.

Figure 1

TSI induces the disturbance of circadian rhythms in rats. (A) Illustration of the experimental setup. Each rat was individually housed in an isolated environment and exposed to a 30-degree head-down tilt by tail suspension for 4 weeks. (B) The curve fitting of the CBT data of rats during the final 7-day period from control and TSI groups (each point represents the average CBT values corresponding to each hourly time point from control and TSI rats). (C–G) Analysis of amplitude (C), daytime (D), night-time (E), mesor (F), and trough phase (G) of the CBT data during the final 7-day period. (H) The curve fitting of the HR data of rats during the final 7-day period from control and TSI groups (each point represents the average HR values corresponding to each hourly time point from control and TSI rats). (I,J) Analysis of amplitude (I) and daytime (J) of the HR data during the final 7-day period. (K) Representative double-plotted actograms of locomotor activity of rats during the 28-day period from control and TSI groups. (L–O) Analysis of amplitude (L), daytime (M), night-time (N), and mesor (O) of the locomotor-activity data during the final 7-day period. * p < 0.05; ** p < 0.01; *** p < 0.001. Data are mean ± S.E.M., n = 6. Two-sided Student’s t tests were used to measure the significance.