Table 2.
Cytokine production in K562 and Lucena cells transwell cultured with MSC-AML and MSC-H.
| Cytokine | K562 | Lucena | ||||
|---|---|---|---|---|---|---|
| MSC-AML | MSC-H | p | MSC-AML | MSC-H | p | |
| CCL2/MCP-1 | 22.8 ± 2.6 | 113.5 ± 11.4 | 0.016 | 17.5 ± 0.7 | 78.5 ± 5.0 | 0.007 |
| CXCL12/SDF-1 | 5.1 ± 1.1 | 8.5 ± 0.1 | 0.082 | 4.4 ± 0.1 | 3.1 ± 0.1 | 0.012 |
| IL-6 | 83.1 ± 2.8 | 65.4 ± 1.1 | 0.027 | 84.5 ± 6.3 | 128.5 ± 1.5 | 0.021 |
| IL-8 | 28.7 ± 2.4 | 15.8 ± 0.1 | 0.033 | 23.9 ± 2.3 | 43.0 ± 2.2 | 0.027 |
| MIF | 27.5 ± 1.8 | 32.8 ± 1.8 | 0.167 | 22.6 ± 1.1 | 20.8 ± 1.1 | 0.369 |
| Serpin E1/PAI-1 | 172.9 ± 5.1 | 188.7 ± 20.9 | 0.540 | 136.8 ± 2.6 | 182.1 ± 2.3 | 0.006 |
MSC-AML: mesenchymal stem cells from acute myeloid leukemia patients; MSC-H: mesenchymal stem cells from healthy donors; CCL2: C-C motif chemokine ligand 2; MCP-1: monocyte chemoattractant protein 1; CXCL12: C-X-C motif chemokine 12; SDF-1: stromal cell-derived factor 1; IL-6: interleukin 6; IL-8: interleukin 8; MIF: macrophage migration inhibitory factor; PAI-1: plasminogen activator inhibitor-1. Data are shown as pixels (mean ± SEM).