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The MS catalytic cycle and its connection to cellular metabolism. Red arrows indicate the pathway of a methyl radical. Abbreviations: MS—methionine synthase, THF—[5,6,7,8]-tetrahydrofolate, DHF—[7,8]-dihydrofolate, Hcy—L-homocysteine, SAH—S-adenosyl-L-homocysteine, SAM—S-adenosyl-L-methionine, GSH—reduced glutathione, MetCbl—MeCbl, Cbl—cobalamin, CH3˙—methyl radical.
