PET/CT with [11C]acetate was conducted at three weeks (A) and three months (B) after right hip arthroplasty using the posterior “Kocher Langerhans” approach. The images depict the iliopsoas and obturator muscles, with the upper and lower rows displaying resting and after-exercise PET, respectively. In each row, from left to right, the images represent PET alone, PET/CT superposition, and low-dose CT alone. The notable surge in [11C]acetate uptake during exercise was similarly observed on the unaffected side of the body in the iliac, psoas, and internal obturator muscles. Conversely, on the operated side, these muscles (indicated by arrows) exhibited similar activity levels during rest and exercise at the 3-week mark. The postsurgical [11C]acetate PET hyperactivity extending into the external obturator muscle on the right side, directly related to the surgical approach, remained stable at rest and exercise. The iliopsoas and obturator muscles affected by surgery ((B), indicated by arrows) show almost complete recovery. [11C]acetate uptake from surgical sites increased with exercise, similar to [11C]acetate uptake from healthy body sites. CT, computed tomography; PET, positron emission tomography. Reproduced from [36], copyright © 2011 Molecular Imaging and Biology.