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. 2024 Apr 26;25(9):4735. doi: 10.3390/ijms25094735

Figure 4.

Figure 4

HMGB1 intracellular signal in H9c2 cells (A,B) Levels of HMGB1 receptor proteins (A) and NFkB signal-associated proteins (B). Right panels, semi-quantified graphs. (CE) Effects of RAGE and/or TLR4 knockdown on apoptosis and autophagy. Statistical significance was calculated using an ordinary ANOVA. Asterisk, p value. C, control; HMGB1, high-mobility group box-1 (40 μg/mL); RAGE, the receptor for advanced glycation end products; TLR4, toll-like receptor 4; IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; pIκBα, phosphorylated IκBα; NFκBp65, nuclear factor of kappa light polypeptide gene enhancer in B-cells; C, control; siC, control short interferent RNA; siRAGE, short interferent RNA to RAGE; siTLR4, short interferent RNA to TLR4.