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. 2024 Apr 26;25(9):4735. doi: 10.3390/ijms25094735

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of BBR on RCN9 rat CRC cells. (A) Effects of BBR on the growth of H9c2 and RCN9 cells. (B,C) Effects of BBR on HMGB1 mRNA expression (B) and HMGB1 protein in the culture medium (C). (D) Effects of BBR on miRNA expression. (E) Effects of miRNA mimics or inhibitors on HMGB1 expression. Statistical significance was calculated using an ordinary ANOVA. HMGB1, HMGB1, high mobility group box-1; ACTB, β-actin; C, control; BBR, berberine; U6, U6 small nuclear 1; mimic, microRNA mimic; Inh, microRNA inhibitor; CM-HMGB1, HMGB1 in the culture medium.