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. 2024 Apr 26;25(9):4735. doi: 10.3390/ijms25094735

Figure 6.

Figure 6

Efforts of BBR on H9c2 cells. (A) Effect of BBR on HMGB1 expression (B,C) Effect of BBR on HMGB1-induced mtHR (B), and NFkB signal proteins (C). Right panels, semi-quantified graph. (D,E) Effect of BBR on apoptosis (D) and the levels of apoptosis-associated proteins (E). Right panels, semi-quantified graph. (F,G) Effect of BBR A on autophagy (F) and the levels of autophagy-associated proteins (G). Right panels, semi-quantified graph. (H) Effects of BBR on myocardial maturation. Statistical significance was calculated using an ordinary ANOVA. Asterisk, p value. C, control; BBR, berberine; HMGB1, high mobility group box-1; RAGE, receptor for advanced glycation end products; TLR4, toll-like receptor 4; mtHR, mitochondrial hydroxyl radical; IκBα, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha; pIκBα, phosphorylated IκBα; NFκBp65, nuclear factor of kappa light polypeptide gene enhancer in B-cells; PARP, poly ADP-ribose polymerase; BCL2, B-cell/CLL lymphoma 2; BAX, Bcl-2-associated X protein; ATG5, autophagy-Related Gene 5; LC3, microtubule-associated protein 1A/1B-light chain 3; SDS-MYL1, sodium dodecyl sulfate-soluble myosin light chain-1.