Table 1.

Comparing the serum anti-JMJD6 antibody (s-JMJD6-Ab) levels between healthy donors (HDs) and patients with chronic cerebral infarction (CCI), acute cerebral infarction (ACI), transient ischemic attack/asymptomatic cerebral infarction (TIA/Asympt-CI), and deep and subcortical white matter hyperintensity (DSWMH).

Sample Information	HD	CCI	ACI	TIA/Asympt-CI	DSWMH
Total sample number	285	65	464	111	162
Male/female	188/97	47/18	271/193	68/43	88/74
Age (median ± SD)	53.5 ± 11.7	73.0 ± 9.3	79.0 ± 11.5	73.0 ± 11.9	67.0 ± 10.0
Patient group	Type of value		s-JMJD6-Ab
HD	Median		7497
	Cutoff value		16,361
	Positive no.		14
	Positive rate (%)		4.9%
CCI	Median		10,118
	Positive no.		13
	Positive rate (%)		20.0%
	p-value (vs. HD)		<0.0001
ACI	Median		10486
	Positive no.		101
	Positive rate (%)		21.8%
	p-value (vs. HD)		<0.0001
TIA/Asympt-CI	Median		10150
	Positive no.		17
	Positive rate (%)		15.3%
	p-value (vs. HD)		<0.0001
DSWMH	Median		8891
	Positive no.		14
	Positive rate (%)		8.6%
	p-value (vs. HD)		0.0025

The upper panel of Table 1 provides detailed information of participants, including the total numbers, the numbers of males and females, and their age distributions (median ± SD). The lower panel summarizes the results of the s-JMJD6-Ab with purified JMJD6 protein as an antigen. Cutoff values for positive antibody levels were determined at the 95th percentile value of the HDs. The p-values were calculated using the Kruskal–Wallis test, and multiple comparisons were conducted using Bonferroni correction. SD, standard deviation; no., number; vs., versus. p-values of <0.05 and positive rates of >10% are marked in bold.