Table 5.
Comparing the serum anti-JMJD6 antibody (s-JMJD6-Ab) levels between healthy donors (HDs) and patients with esophageal cancer (EC), gastric cancer (GC), lung cancer (LC), and mammary cancer (MC).
| Sample Information | HD | EC | GC | LC | MC |
|---|---|---|---|---|---|
| Total sample number | 96 | 192 | 96 | 96 | 96 |
| male/female | 51/45 | 155/37 | 68/28 | 42/54 | 58/38 |
| Age (median ± SD) | 57.0 ± 6.0 | 68.0 ± 9.8 | 69.0 ± 10.6 | 63.0 ± 13.3 | 69.0 ± 9.6 |
| Subject | Type of value | s-JMJD6-Ab | |||
| HD | Median | 734 | |||
| Cutoff value | 2629 | ||||
| Positive no. | 4 | ||||
| Positive rate (%) | 4.2% | ||||
| EC | Median | 1755 | |||
| Positive no. | 67 | ||||
| Positive rate (%) | 34.9% | ||||
| p-value (vs. HD) | <0.0001 | ||||
| GC | Median | 1646 | |||
| Positive no. | 29 | ||||
| Positive rate (%) | 30.2% | ||||
| p-value (vs. HD) | <0.0001 | ||||
| LC | Median | 1140 | |||
| Positive no. | 21 | ||||
| Positive rate (%) | 21.9% | ||||
| p-value (vs. HD) | 0.0031 | ||||
| MC | Median | 992 | |||
| Positive no. | 19 | ||||
| Positive rate (%) | 19.8% | ||||
| p-value (vs. HD) | 0.0054 | ||||
The upper panel of Table 5 provides information on the participants, including the total numbers of samples collected, the numbers of samples obtained from male and female participants, and their age distributions (median ± SD). The lower panel shows the results of the s-JMJD6-Abs with purified JMJD6 protein as an antigen. Positive antibody levels were determined according to the cutoff values set at the 95th percentile of the HDs. The Kruskal–Wallis test and Bonferroni correction were used for p-value calculation and multiple comparisons. SD, standard deviation. no., number. vs., versus. p-values of <0.05 and positive rate of >10% are marked in bold.