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Antibody responses and isotype distribution of virus-specific IgG in mice immunized intraperitoneally. CD4+ T-cell-deficient mice (n = 5) were immunized i.p. with formalin-inactivated PR8 virus (10 μg/mouse) on day 0 and boosted on day 15. Serum samples were collected 15 days after priming and 10 days after boosting. Con, control, unimmunized CD4+ T-cell-deficient mice. Prime, after first immunization. Boost, after boost.
