Table 1.
Comparison of Patient Characteristics, Treatment Volumes, and OARs Dosimetric Parameters in the CTV20 and CTV15 Groups
| CTV20 group | CTV15 group | P | ||
|---|---|---|---|---|
| N | 57 | 56 | ||
| Age (years) | median (range) | 56.4 (33–70) | 55.1 (25–70) | .47* |
| Sex (male) | n (%) | 44 (77.2%) | 37 (66.1%) | .22† |
| Tumor side (left) | n (%) | 38 (66.7%) | 31 (55.4%) | .25† |
| MGMT methylated | n (%) | 29 (50.9%) | 25 (44.6%) | .57† |
| IDH mutated | n (%) | 4 (7.0%) | 6 (10.7%) | .53† |
| Biopsy only | n (%) | 19 (33.3%) | 15 (26.8%) | .54† |
| WHO performance status - 0–1 - 2 - 3 |
n (%) | 42 (73.6%) 14 (24.6%) 1 (1.8%) |
44 (78.6%) 12 (21.4%) 0 |
.45† |
| GTV (cm3) | mean ± SD | 39.7 ± 29.0 | 37.8 ± 23.8 | .71* |
| CTV (cm3) | mean ± SD | 238.9 ± 108.3 | 176. 7 ± 73.2 | .001 * |
| PTV (cm3) | mean ± SD | 292.6 ± 124.1 | 217.0 ± 84.0 | <.001 * |
| Brain Dmean (Gy) | mean ± SD | 25.2 ± 7.8 | 21.0 ± 6.2 | .002 * |
| Hippocampus R Dmean (Gy) | median (IQR) | 11.8 (5.4–26.8) | 7.1 (3.7–49.1) | .20‡ |
| Hippocampus L Dmean (Gy) | median (IQR) | 43.7 (6.7–59.2) | 10.6 (6.0–51.8) | .04 ‡ |
| Hippocampi Dmean (Gy) | median (IQR) | 28.9 (14.7–34.9) | 26.4 (5.4–32.6) | .13‡ |
| Brainstem D0.03cc (Gy) | median (IQR) | 58.8 (36.4–60.2) | 54.1 (24.7–57.8) | <.001 ‡ |
| Optic nerve R D0.03cc (Gy) | median (IQR) | 21.6 (9.4–50.1) | 17.4 (6.0–42.3) | .24‡ |
| Optic nerve L D0.03cc c (Gy) | median (IQR) | 34.5 (11.4–51.3) | 16.0 (8.1–43.7) | .14‡ |
| Optic chiasm D0.03cc (Gy) | median (IQR) | 30.1 (15.8–53.3) | 24.8 (9.3–53.9) | .37‡ |
| Cochlea R Dmean (Gy) | median (IQR) | 6.3 (1.8–13.4) | 2.7 (0.8–8.4) | .01 ‡ |
| Cochlea L Dmean (Gy) | median (IQR) | 9.4 (2.8–29.8) | 2.5 (0.9–11.1) | .001 ‡ |
| Pituitary Gland Dmean (Gy) | median (IQR) | 31.9 (7.9–40.3) | 13.8 (2.4–26.5) | .006 ‡ |
* P-value from t-test; †P-value from chi-square test; ‡P-value from Mann–Whitney test.
Abbreviations: L, left; R, right; Dmean, mean dose; D0.03cc, dose to 0.03cc; OS, overall survival; PFS, progression-free survival; CTV, clinical target volume.