Table 1.

Patient characteristics.

Variable *	Lower Dose	Higher Dose	p
N	22	11	-
Age, y	49 [29, 64]	34 [27, 48]	0.331
Actual weight, kg	83 [68, 102]	82 [72, 90]	0.789
Ideal body weight, kg	65 (59, 75)	71 (66, 78)	0.292
Adjusted dosing weight, kg	76 [68, 85]	75 [72, 84]	0.619
Body mass index, kg/m2	26.3 [23.0, 33.1]	27.0 [24.5, 28.8]	0.717
Sex, male/female, n/n	14/8	9/2	0.430
Race
Black, n	13	7	0.586
White, n	7	4
Hispanic, n	2	0
Admission diagnosis
Motor vehicle collision, n	16	7	0.329
GSW/KSW, n	2	3
Fall/assault, n	1	1
Other, n	3	0
Severe TBI with ICP monitoring, n (%)	7 (32%)	2 (18%)	0.681
Ventilator dependent, n	21 (95%)	11 (100%)	1.000
TICU length of stay, d	14 [9, 19]	14 [12, 18]	0.515
Hospital length of stay, d	28 [18, 45]	21 [19, 41]	0.390
Ventilator dependent, n (%)	21 (95%)	11 (100%)	1.000
Survived, n (%)	17 (77%)	10 (91%)	0.637
Serum potassium, mEq/L	4.2 [4.0, 4.3]	4.2 [4.0, 4.4]	0.546
mmol/L	4.2 [4.0, 4.3]	4.2 [4.0, 4.4]
White blood cell count, cells/µm3	10.7 [9.3, 13.5]	10.5 [7.8. 14.3]	0.717
Serum magnesium, mg/dL	2.0 [2.0, 2.1]	1.8 [1.7, 2.1]	0.055
mmol/L	0.82 [0.82, 0.86]	0.74 [0.70, 0.86]
C-reactive protein, mg/dL	25.0 [17.9, 34.3]	18.1 [10.9, 31.8]	0.172
mg/L	250 [179, 343]	181 [109, 318]
Prealbumin, mg/dL	9.0 [4.5, 13.5]	10.0 [7.0, 14.3]	0.364
mg/L	90 [45, 135]	100 [70, 143]
Serum creatinine, mg/dL	0.8 [0.6, 1.0]	0.8 [0.7, 0.9]	0.907
µmol/L	71 [53, 88]	77 [62, 80]
Serum urea nitrogen, mg/dL	18 [13, 27]	18 [10, 27]	0.804
mmol/L	6.4 [4.6, 9.6]	6.4 [3.6, 9.6]
Serum glucose, mg/dL	135 [113, 164]	113 [104, 122]	0.070
mmol/L	7.5 [6.3, 9.1]	6.3 [5.8, 6.8]
Total fluid intake, L/d	2.9 [2.2, 3.5]	3.1 [1.8, 3.4]	0.954
Total fluid output, L/d	1.9 [1.4, 3.0]	2.2 [1.1, 3.7]	0.554
Received vasopressors during EN, n (%)	2 (9%)	1 (9%)	1.000

* d, day; GSW, gunshot wound; KSW, knife stab wound; ICP, intracranial pressure; TBI, traumatic brain injury; TICU, trauma intensive care unit.