Table 2.
Response to enteral phosphorus therapy.
| Variable * | Lower Dose | Higher Dose | p |
|---|---|---|---|
| Number of patients, n | 22 | 11 | - |
| Phosphorus dose, mmol | 34 | 68 | - |
| Phosphorus dose, mmol/kg dosing weight | 0.45 [0.40, 0.50] | 0.91 [0.81, 0.94] | 0.001 |
| EN phosphorus intake, mmol ¶ | 19.5 [8.8, 34] | 24 [12, 33] | 0.789 |
| Day of EN, d ¶ | 2 [1, 7] | 2 [1, 4] | 0.556 |
| TICU day, d ¶, | 5 [3, 10] | 4 [2, 6] | 0.317 |
| Caloric intake, kcals/d ¶ | 899 [423, 1405] | 1035 [443, 1513] | 0.717 |
| Carbohydrate intake, g/d ¶ | 64 [39, 136] | 107 [55, 161] | 0.480 |
| Insulin intake, units/d ¶ | 0 [0, 3] | 0 [0, 0] | 0.477 |
| Arterial pH pre-dose | 7.42 [7.36, 7.47] | 7.42 [7.37, 7.45] | 0.560 |
| Arterial pH post-dose | 7.45 [7.39, 7.49] | 7.44 [7.29, 7.50] | 0.830 |
| Initial serum phosphorus, mg/dL | 2.6 [2.4, 2.8] | 2.5 [2.1, 2.8] | 0.465 |
| mmol/L | 0.84 [0.77, 0.90] | 0.81 [0.68, 0.90] | |
| Final serum phosphorus, mg/dL | 2.8 [1.9, 3.3] | 2.9 [2.2, 3.0] | 0.878 |
| mmol/L | 0.90 [0.61, 1.07] | 0.94 [0.71, 0.97] | |
| ∆ in serum phosphorus, mg/dL | 0.2 [−0.5, 0.7] | 0.6 [−0.3, 0.8] | 0.646 |
| mmol/L | 0.06 [−0.16, 0.23] | 0.19 [−0.10, 0.26] | |
| Improvement in serum phosphorus, n (%) |
12 (55%) | 8 (73%) | 0.436 |
| Initial serum iCa, mmol/L | 1.11 [1.07, 1.17] | 1.14 [1.11, 1.15] | 0.984 |
| Final serum iCa, mmol/L | 1.15 [1.09, 1.20] | 1.12 [1.08, 1.16] | 0.251 |
| Diarrhea, n (%) | 3 (14%) | 0 (0%) | 0.534 |
¶ on day of phosphorus therapy. * EN, enteral nutrition; iCa, ionized calcium concentration. TICU, trauma intensive care unit; ∆, change.