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. 2024 May 8;19(1):2349980. doi: 10.1080/15592294.2024.2349980

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Disease-free survival (DFS) for patients treated with FU/LV vs IFL based on ZNF331 promoter methylation status. Interaction of ZNF331 promoter methylation status and treatment arm on disease-free survival: (a) unmethylated ZNF331 and (b) methylated ZNF331. There was no observed difference in DFS based on a two-way interaction model between treatment arm and ZNF331 promoter methylation status. (c) Evaluation of ZNF331 promoter methylation status as a predictive marker of DFS.